All About Albumin: Biochemistry, Genetics, and Medical by Theodore Peters Jr. PDF

By Theodore Peters Jr.

ISBN-10: 0125521103

ISBN-13: 9780125521109

The 1st of its style, All approximately Albumin summarizes the chemistry, genetics, metabolism, medical implications, and advertisement points of albumin. It offers the main updated sequences, buildings, and compositions of many species, and comprises greater than 2000 references.

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Extra resources for All About Albumin: Biochemistry, Genetics, and Medical Applications

Example text

Some physical chemical properties of albumins. (a) Molar absorptivity; (b) fluorescence emission (relative); (c) mean residue ellipticity by CD; (d) acid-base titration curve. Solid lines, BSA; dashed lines, HSA. The titration curves of HSA and BSA do not differ significantly. Modified from Peters (1975) and Steinhardt et al. ( 1971 ), with permission of the publishers. (b) Reprinted with permission from Steinhardt et al. ( 1971 ). Copyright 1971 American Chemical Society. II. Tertiary Structure and Physical Chemical Behavior 41 absorbance is very high but is strongly affected by traces of turbidity or the presence of carboxyl or hydroxyl ions, and its measurement places severe requirements on the optics of the spectrophotometer and the purity of the albumin solutions.

02 pH unit even after 30 min at pH 12 or 24 h at pH 2mwithout hysteresis, affirming the resiliency of the albumin molecule. 5 pH units less than those typical of other proteins.

1983), compared to 19 A by X-ray. , 1983); Hagag et al. ~. 2 ,~ from Tyr-411" X-ray diffraction found a greater distance, ~36 ]k, which He and Carter (1992) conjectured may be due to experimental error and lack of knowledge about the orientation of the fluorescent probe on Tyr-411 and the quencher on Cys-34. Unfortunately, the atomic coordinates of the He and Carter model have not been made public, so that the scientific community cannot make its own distance computations or other assessments.

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All About Albumin: Biochemistry, Genetics, and Medical Applications by Theodore Peters Jr.

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