By Eveline S. Litscher, Paul M. Wassarman
This e-book presents a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details to be had for the zona pellucida area protein kin, which effect pathologies comparable to infertility, deafness, and melanoma. additionally it:
- Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
- Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
- Speculates as to the evolution of the ZP area and capability therapeutics for ailments stemming from ZP area mutations
- Addresses mammalian and non-mammalian systems
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Additional info for A Guide to Zona Pellucida Domain Proteins
Marsupials give birth to their young at a relatively early age (gestation 4–5 weeks) and newborn infants develop for several months in the protective pouch of their mother. In general, the marsupial oocyte is larger than the oocyte of placental mammals and the ZP is thinner, ranging from 1 to 7 µm in width. 5). The possum ZP consists of three proteins, called ZP2–4, with estimated MWs of ≃92, ≃62, and ≃137 kD, respectively. zp2, 3, and 4 are expressed exclusively in the ovary and have been cloned and sequenced.
The aa sequence of the CTP of mZP3, from aa 350–424, is shown together with the positions of the CFCS, EHP, TMD, and CT. Note that the IHP is located in the ZP‐N sub‐domain of the ZPD and that the EHP is located between the CFCS and TMD. secretion but is required for cleavage at the CFCS and ensures proper localization and/or topological orientation of nascent ZP proteins so that assembly can take place. The carboxy-terminal propeptide (CTP) of nascent mZP1–3 possesses a short, hydrophilic cytoplasmic tail (CT) downstream of the TMD.
The propensity of purified mZP1, 2, and 3 to form higher order oligomers in vitro and the failure to construct a ZP around mouse oocytes that do not synthesize either mZP2 or 3 is consistent with this model for ZP fibrils. Prior to incorporation into the oocyte’s ZP, nascent mZP2 and 3 polypeptides are processed at their CFCS, located close to the C‐terminus of the polypeptides, by a member of the furin family of serine proteases. All three nascent ZP proteins have a TMD downstream of the CFCS.
A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman